This clinical study observes the direct link between insulin resistance and prostate tissue growth. Hyperinsulinemia has been identified as a crucial metabolic factor that can accelerate cellular proliferation in the prostate, contributing significantly to the development of Benign Prostatic Hyperplasia (BPH).
The research highlights that patients with elevated fasting insulin levels showed a significantly higher prostatic volume compared to the control group. Insulin receptor signaling and insulin-like growth factor 1 (IGF-1) play a fundamental role in this mitogenic process.